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Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-14

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Protein Data Bank Japan2025-11-05 更新2026-04-19 收录
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Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-14 Descriptor: 4-chloranyl-1,1-bis(oxidanylidene)-~{N}-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Wu, D, Zhuang, J, Li, F, Chen, X, Diao, X. Deposit date: 2025-01-15 Release date: 2025-10-15 Last modified: 2025-11-05 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structure-Based Optimization of HIF-2 alpha Agonists That Synergistically Enhance Erythropoietin Production with PHD Inhibitors. J.Med.Chem., 68, 2025
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2025-01-15
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