Puri2010 - Mathematical Modeling for the Pathogenesis of Alzheimer's Disease

Puri2010 - Mathematical Modeling for the
Pathogenesis of Alzheimer's Disease

Puri2010 - Mathematical Modeling for the Pathogenesis of
Alzheimer's Disease

Encoded non-curated model. Issues:

- Confusing replacement of 
α16
when t = 3 years
- Confusing 4th rate equation

This model is described in the article:

Mathematical modeling for
the pathogenesis of Alzheimer's disease.

Puri IK, Li L.
PLoS ONE 2010; 5(12): e15176
Abstract:

Despite extensive research, the pathogenesis of
neurodegenerative Alzheimer's disease (AD) still eludes our
comprehension. This is largely due to complex and dynamic
cross-talks that occur among multiple cell types throughout the
aging process. We present a mathematical model that helps
define critical components of AD pathogenesis based on
differential rate equations that represent the known
cross-talks involving microglia, astroglia, neurons, and
amyloid-? (A?). We demonstrate that the inflammatory activation
of microglia serves as a key node for progressive
neurodegeneration. Our analysis reveals that targeting
microglia may hold potential promise in the prevention and
treatment of AD.

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