Genome-wide identification and DNA methylation of human full-length LINE-1 (L1) retrotransposons in a panel of embryonic stem cells, induced-pluripotent stem cells and their progenitor cells

We used bs-ATLAS-seq to comprehensively map the genomic location and assess the DNA methylation status of human full-length LINE-1 elements (L1). The approach is focused on the youngest family (L1HS), but it also catches a significant fraction of L1PA2 to L1PA8 elements. This was performed in a panel of embryonic stem cells, induced-pluripotent stem cells and their progenitor cells, at different passages.