Crystal structure of CDK2 in complex with Cpd 2
收藏Protein Data Bank Japan2025-04-30 更新2026-04-19 收录
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Crystal structure of CDK2 in complex with Cpd 2 Descriptor: 6-chloro-8-cyclopentyl-2-[4-(ethanesulfonyl)-2-methylanilino]pyrido[2,3-d]pyrimidin-7(8H)-one, Cyclin-dependent kinase 2 Authors: Kwiatkowski, N, Liang, T, Sha, Z, Collier, P.N, Yang, A, Sathappa, M, Paul, A, Su, L, Zheng, X, Aversa, R, Li, K, Mehovic, R, Breitkopf, S.B, Chen, D, Howarth, C.L, Yuan, K, Jo, H, Growney, J.D, Weiss, M, Williams, J. Deposit date: 2024-08-07 Release date: 2025-04-16 Last modified: 2025-04-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers. Cell Chem Biol, 32, 2025
创建时间：
2024-08-07
