BIOGRID CURATED DATA FOR MRE-11 (Caenorhabditis elegans)

Protein-Protein, Genetic, and Chemical Interactions for MRE-11 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: mre-11 encodes a protein orthologous to S. cerevisiae MRE11 and to human MRE11A (OMIM:600814, mutated in ataxia-telangiectasia-like disorder); MRE-11 is required for meiotic recombination and DNA repair in C. elegans, for multigenerational persistence of the germline, and (in conjunction with CHK-2 and SPO-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei.

MRE-11蛋白质-蛋白质、遗传和化学相互作用数据集，由BioGRID（https://thebiogrid.org）精心编纂；定义：mre-11基因编码的蛋白与酿酒酵母中的MRE11蛋白以及人类中的MRE11A蛋白（OMIM:600814，突变会导致共济失调性毛细血管扩张症）同源；MRE-11在秀丽隐杆线虫中对于减数分裂重组和DNA修复至关重要，确保生殖细胞的跨代持久性，并且（与CHK-2和SPO-11协同作用）使RAD-51定位到晚合子期/早期厚化期核中的焦点。