Logistic regression odds ratio (and 95%CI) for faster progression* by SNCA Rep1 genotypes defined by the 259 base pair allele vs others (dominant model).

All analyses are adjusted for age at diagnosis (continuous), gender (male/female), smoking status (never/ever), duration of time between PD diagnosis and baseline assessment (in years), and baseline UPDRS motor score.Abbreviations: SNCA = alpha-synuclein; OR = odds ratio; CI = confidence interval; p = p-value; n = number.Subgroup #1, subjects with off-medication exams only.Subgroup #2, subject with complete UPDRS data at both baseline and follow-up exams.*Faster progression defined as ≥5 point change in motor UPDRS annually.§259 non-carriers include genotypes 261/261, 261/263, or 263/263; 259 carriers include genotypes 259/259, 259/261 or 259/263.†P-value the additive (or allele dosage) genetic model.