Drug efflux and lipid A modification by 4-L-aminoarabinose are key mechanisms of polymyxin B resistance in the sepsis pathogen Enterobacter bugandensis. Drug efflux and lipid A modification by 4-L-aminoarabinose are key mechanisms of polymyxin B resistance in the sepsis pathogen Enterobacter bugandensis

To investigate the mechanism of PmB resistance and heteroresistance in Enterobacter bugandensis by analysing the differential gene expression under PmB treatment. Overall design: Comparative gene expression profiling analysis of RNA-seq data for two Enterobacter bugandensis strains, E105227 and E104107, on presence and absence of the antibiotic PmB. The RNA was extracted from cells growing in exponential phase and 3 replicates were done for each condition and strain.