Unveiling Chondrocytes as the Key Osteosarcoma Cell of Origin and Genetic Profiling of its Progression

Osteosarcoma (OS) is a primary bone tumor mainly affecting teenagers and young adults. Despite extensive research, the 5-year survival rate for metastatic OS remains low. Our mission is to develop more sensitive methods for detecting early metastatic cells to improve survival rates. We've genetically engineered mice, deleting genes p53 and Rb1 in growth plate cells, tagged with red fluorescence to track their development. These data contain genome and transcriptome sequences from these mice.