wired together, change together: spike timing modifies transmission in converging assemblies

The precise timing of neuronal spikes may lead to changes in synaptic connectivity and is thought to be crucial for learning and memory. However, the effect of spike timing on neuronal connectivity in the intact brain remains unknown. Using closed-loop optogenetic stimulation in CA1 of freely moving mice, we generated unique spike patterns between presynaptic pyramidal cells (PYRs) and postsynaptic parvalbumin (PV)–immunoreactive cells. The stimulation led to spike transmission changes that occurred together across all presynaptic PYRs connected to the same postsynaptic PV cell. The precise timing of all presynaptic and postsynaptic cell spikes affected transmission changes. These findings reveal an unexpected plasticity mechanism, in which the spike timing of an entire cell assembly has a more substantial impact on effective connectivity than that of individual cell pairs., , , # Wired together, change together: Spike timing modifies transmission in converging assemblies

This dataset encompasses extracellular recordings obtained from freely moving mice, integral to the research presented in our manuscript titled \"Wired together, change together: Spike timing modifies transmission in converging assemblies.\" The data primarily consist of neuronal spike timing, LFP, optogenetic stimulation, and other useful information for working with the dataset.

## Description of the data and file structure

The dataset is organized by session, with each folder containing data from a single session. Folders ending with a number (e.g., mP79_20) encompass data from the closed-loop experiment sessions. In contrast, folders ending with 'Control' contain data from control sessions, where no stimulation was administered during the defined 'Before' and 'After' periods.

Within each folder, data are further categorized into subfolders named according to the specific session. Each ...