To gain insight into the mechanisms by which exercise affects circulating immune cells, we subjected young and old mice to aerobic exercise and performed single cell transcriptome analysis of circulat
Pro-regenerative macrophages are well known for their role in promoting tissue repair, however in aging macrophage numbers are reduced acutely and repair following nerve injury deminished. Macrophage-
Single cell RNA sequencing from lungs of young (2-3 month old) and aged (20-22 month old) mice. Myeloid cells (CD45+ Gr1+ CD11b+) were sorted from lungs of young and aged mice that were perfused. Cell
We previously identified a population of IL-10-producing, T follicular helper-like cells ("Tfh10"), linked to suppressed vaccine responses in aged mice. Here, we applied scRNA-seq and scATAC-seq to ch
