Parameter sets used to generate networks from the protein structures in the T4L-TEM-HIVP and FSSP128 sets.

Dmin (?): Minimum distance of separation in Angstroms (?) between atoms or residues.Dmax (?): Maximum distance of separation (?) between atoms or residues. Dcriterion: If once, residues were paired if at least one atom in each residue was within the specified D value. If average, the distance between the centers of mass of the residues was taken. Pairing: 4 rules for pairing residues were implemented: ch: the two residues are polar or charged and have complementary charges, ch+h: the two residues have complementary charges or both are hydrophobic, h: the two residues were hydrophobic and all: any two residues were paired. Error: An estimation of the reliability of the predictions of critical residues achieved using the corresponding network: the smaller the error the better the prediction (see Methods). The Error is indicated here only for the T4L-TEM-HIVP set.