Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I)

Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I) Descriptor: Cellular tumor antigen p53, DNA target, FORMIC ACID, ... Authors: Rozenberg, H, Degtjarik, O, Shakked, Z. Deposit date: 2020-12-02 Release date: 2021-12-08 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021