FIBRODYSPLASIA OSSIFICANS PROGRESSIVA: ETHIO-PATHOGENETIC MECHANISMS, CLINICAL MANIFESTATION, MODERN TREATMENT, AND PROPHYLACTIC RESTRICTIONS

This article analyzes the etiopathogenesis, clinical course, and diagnostic criteria of Fibrodysplasia Ossificans Progressiva (FOP), an extremely rare and progressive hereditary pathology. The mechanisms by which ACVR1 gene mutations and BMP signaling pathway dysregulation lead to heterotopic ossification (ossification) of muscle, tendon, and ligamentous tissues are highlighted. The study clinically substantiates specific clinical manifestations of the pathology (malformation of the great toes, flare-ups), modern pharmacotherapy (palovaroten), and preventive restrictions aimed at preventing iatrogenic complications.