Crystal structure of JAK3 kinase domain in complex with an indazole substituted pyrrolopyrazine inhibitor
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Crystal structure of JAK3 kinase domain in complex with an indazole substituted pyrrolopyrazine inhibitor Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, ... Authors: Kuglstatter, A, Jestel, A, Nagel, S, Boettcher, J, Blaesse, M. Deposit date: 2012-11-16 Release date: 2013-09-25 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Strategic Use of Conformational Bias and Structure Based Design to Identify Potent Jak3 Inhibitors with Improved Selectivity Against the Jak Family and the Kinome. Bioorg.Med.Chem.Lett., 23, 2013
创建时间：
2012-11-16
