Additional file 2 of Unraveling the causality between chronic obstructive pulmonary disease and its common comorbidities using bidirectional Mendelian randomization

Additional file 2: Table S1. STROBE-MR checklist of Mendelian randomization study. Table S2. The comprehensive retrieved results of traits corresponding to SNPs in Penoscanncer V2 and GWAS catalog. Table S3. Comprehensive details of incorporated SNPs for each disease investigated (R2<0.001). Table S4. Sample overlap rate between exposure and outcome and potential bias. Table S5. The UVMR results of COPD to its frequently coexisting comorbidities (R2<0.001). Table S6. Pleiotropy and heterogeneity analysis of concerned forward UVMR analysis (R2<0.001). Table S7. The reverse UVMR results of COPD to its frequently coexisting comorbidities (R2<0.001). Table S8. Pleiotropy and heterogeneity analysis of concerned reverse UVMR analysis (R2<0.001). Table S9. The MVMR results with adjusting the smoking exposure (R2<0.001). Table S10. Comprehensive details of incorporated SNPs for each disease investigated (R2<0.01). Table S11. The UVMR results of COPD to its frequently coexisting comorbidities (R2<0.01). Table S12. Pleiotropy and heterogeneity analysis of concerned forward UVMR analysis (R2<0.01). Table S13. The reverse UVMR results of COPD to its frequently coexisting comorbidities (R2<0.01). Table S14. Pleiotropy and heterogeneity analysis of concerned reverse UVMR analysis (R2<0.01).