Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-controlled Gene Expression are Perturbed in Liver-Specific METTL3 Knockout Mice

METTL3 is essential for ESC differentiation and embryonic development, and its dysregulation is linked to various diseases including metabolic disorders and cancer. However, the consequence of m6A perturbation in the mammalian liver is not understood. Here, we provide insight into this by generating mice M3LKO (Mettl3fl/fl; Alb-Cre) mice carrying a hepatocyte-specific deletion of Mettl3. Liver mRNA profiles of 5-week old wild type and Mettl3 liver specific knockout mice