S. aureus DHFR complexed with NADPH and iclaprim

S. aureus DHFR complexed with NADPH and iclaprim Descriptor: 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Oefner, C, Dale-Glenn, E. Deposit date: 2009-01-08 Release date: 2010-01-12 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity J.Antimicrob.Chemother., 63, 2009