WT and aP2-Cre Adipocyte Bmal1 KO 24hr Time Course, Liver Tissue RNA-seq

Liver metabolism in mice lacking Bmal1 in adipocytes. Comparison between WT and KO revealed no differentially expressed genes at ZT12 and ZT16, and only revealed one gene at ZT8 and ZT20. In contrast many genes were differential at ZT0 and ZT4. With ZT4 having substantially more than ZT0. Time-series liver mRNA profiles of 4- to 6-month-old male wild type (WT) and Bmal1 knockout (KO) mice were generated by sequencing, four mice per genotype per timepoint, using Illumina HiSeq 2000.