Enantioselective Palladium-Catalyzed Intramolecular α‑Arylative Desymmetrization of 1,3-Diketones

An efficient enantioselective protocol
has been reported to build
highly oxygenated and densely substituted bicyclo­[m.n.1] skeletons through intramolecular asymmetric
α-arylative desymmetrization of 1,3-diketones. Employing Pd
catalyst and FOXAP ligand, various bicyclo­[m.n.1] skeleton with different size can be accessed with high
enantio- and diastereoselectivities. Utilizing the present method
as a key step, formal asymmetric total synthesis of the (−)-parvifoline
has been demonstrated.