Altered expression of PBMC miRNA profile following the third dose of inactivated COVID-19 vaccine. Altered expression of PBMC miRNA profile following the third dose of inactivated COVID-19 vaccine

COVID-19 vaccination is the most effective approach to prevent severe disease and death. Inactivated vaccines are the most accessible type of COVID-19 vaccines in the developing countries. Several studies, including work from our group, have demonstrated that the third (booster) dose of inactivated COVID-19 vaccine induces robust humoral and cellular immune responses. The aim of this study was to examine miRNA expression profile in participants received a homogenous third dose of the CoronaVac vaccine. Overall design: The discovery and validation cohorts included 6 volunteers.Samples of peripheral blood mononuclear cells (PBMCs) were harvested from healthcare volunteers before and 1-2 weeks after the third dose of CoronaVac.