Alternative platelet differentiation pathways initiated by non-hierarchically related hematopoietic stem cells

ChEBI2024-06-02 更新2026-07-12 收录

血小板生成

干细胞异质性

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-13935 数据链接链接失效反馈

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Alternative platelet differentiation pathways initiated by non-hierarchically related hematopoietic stem cells

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2024-06-02

Inhibition of O-GlcNAcylation via O-GlcNAc transferase fosters megakaryopoiesis and induces thrombopoiesis

巨核细胞分化

血小板生成

We report that cellular O-GlcNAcylation levels decline along the course of megakaryocyte (MK) differentiation from human-derived hematopoietic stem and progenitor cells (HSPCs) and that inhibition of

NIAID Data Ecosystem90

Transcriptome profiling of muscle stem cell subpopulations based on differential expression of Myf5. Transcriptome profiling of muscle stem cell subpopulations based on differential expression of Myf5

干细胞异质性

转录组学分析

To identify genes and pathways differentially expressed in Myf5 subpopulations of muscle stem cells Overall design: Myf5 subpopulations (Myf5High and Myf5Low) of muscle stem cells were isolated from h

NIAID Data Ecosystem40

Gene Expression profile at the single cell level of quiescent and activated muscle stem cells (MuSC) from Extraocular muscle (EOM) and Tibialis Anterior (TA) muscle. Gene Expression profile at the single cell level of quiescent and activated muscle stem cells (MuSC) from Extraocular muscle (EOM) and Tibialis Anterior (TA) muscle

单细胞转录组学

干细胞异质性

Skeletal muscle stem cells (MuSCs) are recognised as functionally heterogeneous. Cranial MuSCs are reported to have greater proliferative and regenerative capacity when compared with those in the limb

NIAID Data Ecosystem20

Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets

细胞重编程

血小板生成

The shortage of platelets is becoming increasingly prominent owing to their short shelf life, limited supply, and increasing demand in response to public health incidents. It is an attractive idea to

NIAID Data Ecosystem50

Expression of thioredoxin-interacting protein (TXNIP) during megakaryopoiesis is indispensable for platelet biogenesis

血小板生成

巨核细胞分化

Thioredoxin-interacting protein (TXNIP) is ubiquitously expressed in blood cells, including hematopoietic stem cells (HSCs), monocytes, and platelets. Here we report a novel finding that TXNIP plays a

NIAID Data Ecosystem30

Alternative platelet differentiation pathways initiated by non-hierarchically related hematopoietic stem cells

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