DATA TABLES - The urine metabolic signature of distal diuretics

We assessed the urinary metabolomic fingerprint of treatment with amiloride and hydrochlorothiazide in individuals with CKD stage G3-G4. We identified enhanced ammoniagenesis in the absence of hypokalemia or metabolic acidosis. Patients who developed diuretic-induced hyponatremia exhibited a urinary metabolomic signature of oxidative stress. Our study highlights the interplay between <i>electrolyte and fluid balance</i> and <i>metabolic adaptations</i> in individuals with CKD who are treated with distal diuretics.