The median values of the PD parameter estimates of VPA in the final population PK-PD models obtained using the NONMEM program and the bootstrap analysis.

VPA = valproic acid; PD = pharmacodynamic; PK = pharmacokinetic; NONMEM = nonlinear mixed-effect model; RES = relative standard error; CIs = confidence intervals; Dose = daily dose of VPA; BASE = intercept; SLOPE = slope relating the AUC of VPA; SOD2 = superoxide dismutase 2; ω = coefficient of variation of inter-individual variability; logit (Pr) = logit function of probability of having an elevated γ-GT level.The median values of the PD parameter estimates of VPA in the final population PK-PD models obtained using the NONMEM program and the bootstrap analysis.