Characteristics of the PMF profiles calculated for the dimers in DOPC and POPC bilayers.

The PMFs correspond to the separation of the monomers associated in right-handed interactions (R). The PMF profile was calculated in the case of the separation of the PLXA1 monomers associated in left-handed (L) within a DOPC bilayer. Emin is the difference in free energy between the associated state and the full separation of the monomers. Dmin is the distance separating the center of mass of the backbone beads of the two helices at the minimum of the PMF profile. is the difference between the apparent dissociation free energy of the PLXA1 homodimer or the heterodimer (i) and the apparent dissociation free energy of the NRP1 homodimer (see equation 2). Energies are given in kJ mol−1 and distances are in nm.