RNA-sequencing from human salivary glands from Sjogren's disease patients recruited in the TRACTISS randomized clinical trial

Sjogren's disease patients received Rituximab (anti-CD20 depleting monoclonal antibody) or placebo treatment. This study aims to identify the transcriptomic features of salivary gland biopsies, the target tissue of the autoimmune response in Sjögren's disease. It examines transcriptomic changes in salivary gland tissue from patients treated with Rituximab compared to those in the placebo group, alongside longitudinal changes pre/post treatment.