ABI1-based 7-gene expression signature predicts breast cancer metastasis and survival

Collection of human breast cancer gene expressed measured by GPL2567. This subpopulation of breast cancer has gene expression and clinical data which were used for survival prediction analysis; resulting in emphasizing the ABI1-based 7-gene prognostic signature, as a prospective multi-gene expression clinical biomarker of breast cancer aggressiveness and metastasis, and therapeutic target. 295 breast cancer samples from human patients were taken. Gene expression was measured using the GPL2567 dual-channel microarray platform. Clinical data including lymph node and estrogen receptor (ER) status, disease free, metastasis, and overall survival times were measured. This dataset was used to develop a prognostic signature of metastatic breast cancer defined by our ABI1-based prognostic signature.