Additional file 1 of RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development

Additional file1. Table S1. Differentially expressed genes in affected plantar hyperkeratosic skin of RSPO1-mutated patient vs plantar control - Affimetrix microarrays U133a Raw data).Values in the Signal column reflect intensity. The Detection column assigns a call of Present, Absent, or Marginal to each probe set and the “Detection p-value” column provides an assessment of statistical significance of each call. The “Descriptions” column provides summary information about each transcript. Table S2. Differentially expressed genes in affected plantar hyperkeratosic skin of RSPO1-mutated patient vs plantar control - Affimetrix microarrays U133b Raw data).Values in the Signal column reflect intensity. The Detection column assigns a call of “Present, Absent, or Marginal to each probe set and the Detection p-value column provides an assessment of statistical significance of each call. The Descriptions column provides summary information about each transcript. Table S3. Differentially expressed genes in affected plantar hyperkeratosic skin of RSPO1-mutated patient vs plantar control. Table S3 summarizes 1747 differentially expressed genes with detection p value <0.05 in both samples and a >2.0 or <0.5 ANp/Cp fold change. Table S4. Individual identification of GO-enriched genes differentially expressed genes in affected plantar hyperkeratosic skin of RSPO1-mutated patient vs plantar control.Genes in Supplementary Table S3 were filtered for Gene Ontology (GO)-annotated genes and clustered in biological processes. Individual identified GO-enriched genes are reported.