Minor allele frequencies (MAF) and genotype counts in 684 diabetic nephropathy cases and 710 no nephropathy diabetic controls.
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aMinor alleles are presented first followed by major allele.bUnadjusted P values were calculated as tests for trend (1 df) across genotypes.cOdds ratios and 95% confidence intervals are calculated on a per allele basis for the minor allele assuming an additive model.dAdjusted P values were calculated as tests for trend (1 df) across genotypes in a logistic regression which included terms for collection center, gender, duration of T1DM and HbA1c category. Associations were no longer significant after correction for multiple testing performed by permutation test (n = 100,000).eIn a sensitivity analysis (Control samples only with eGFR>60 ml/min/1.73 m2; n = 444) adjusted P values were calculated as tests for trend (1 df) across genotypes in a logistic regression which included terms for collection center, gender, duration of T1DM and HbA1c category. Associations were no longer significant after correction for multiple testing performed by permutation test (n = 100,000).1Proxy for rs599839 (r2 = 0.90).2Proxy for rs17145738 (r2 = 1).3Proxy for rs17321515 (r2 = 0.97).4Proxy for rs16996148 (r2 = 0.90).5Proxy for rs16996148 (r2 = 1).
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2015-12-02



