LNCRNA Illumina sequencing results associated with renal fibrosis disease progression

Objective: To screen and identify long noncoding RNAs (lncRNAs) involved in the progression of renal fibrosis and to explore their functions. Methods: We used unilateral ureteral obstruction (UUO) to establish a rat model of renal fibrosis. The animals were randomly divided into four groups: control, model group at 2 weeks (MOD-2), MOD-4, and MOD-6. Renal function was monitored by measuring the levels of conventional biochemical biomarkers. Differentially expressed lncRNAs (DE-lncRNAs) between the control and model groups were screened, and their functions were annotated using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis. Gene interaction networks were visualized using Cytoscape.
Results: Transcriptomic analysis revealed 243 DE-lncRNAs (82 upregulated, 161 downregulated) in the MOD-2 group compared with the control group, 216 DE-lncRNAs (95 upregulated, 121 downregulated) in the MOD-4 group, and 70 DE-lncRNAs (39 upregulated, 31 downregulated) in the MOD-6 group. C..., , , # LNCRNA Illumina sequencing results associated with renal fibrosis disease progression

[https://doi.org/10.5061/dryad.g4f4qrfxw](https://doi.org/10.5061/dryad.g4f4qrfxw)

The original image data files obtained by Illumina HiSeq sequencing platform during rat renal fibrosis process were converted into Sequenced Reads by Base Calling analysis. We call this Raw Data or Raw Reads.

## Description of the data and file structure

1 and 2 in the file name represent Paired-end sequence files respectively

Description of the result file:

The fq.gz file is the original sequencing sequence of high throughput sequencing, and the results are stored in FASTQ file format. Inclusive test

Sequence information of sequence sequence and corresponding sequencing quality information. Each read in the FASTQ file is described by four lines,

Its format is as follows:

@HWI-ST1276:71:C1162ACXX:1:1101:1208:2458 2:N:0:CGATG

CTGGCTCCGGAGGGGATGGAGGCGGCACTCCCGCCAAGGATGCGTTG...

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BCBFFFFDHHHHHJJ? EAGIIIAHIJII...