Drug development is both increasing in cost whilst decreasing in productivity. There is a general acceptance that the current paradigm of R&D needs to change. One alternative approach is drug repositi

NIAID Data Ecosystem80

Rare SNVs identified with amino acid changes and computational predictions of pathogenicity.

遗传变异致病性

疾病关联分析

1)PolyPhen2 scores close to 1 are likely to be pathogenic (highlighted in bold). HumDiv-trained Polyphen-2 assumes even mildly deleterious alleles as damaging to evaluate rare alleles potentially invo

Figshare2015-12-02 更新40

Additional file 3: Table S3. of DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

炎症相关DNA甲基化

疾病关联分析

Discovery and replication results of the 218 significant associations in the discovery population. (XLSX 41 kb)

NIAID Data Ecosystem100

Additional file 1: Table S1. of A method for automated pathogenic content estimation with application to rheumatoid arthritis

微生物组病原体识别

疾病关联分析

Human bacteria pathogens in a Genus-Species table collected from six public database and manual searching, this table is integral to the eudysbiome package, reported here for convenience. (XLSX 73 kb)

Figshare2016-12-14 更新50