Differential expression of Organ Transplant Rejection related genes after xenokidney from 1KO.1TG vs. 3KO.7TG donor pigs

Animals received 3KO.7TG showed a distinct pattern of gene expression compared to those received 1KO.1TG After weaning immunosuppression, Animals received 3KO.7TG showed elevation of genes related to neutrophil degranulation, coagulation pathway, B cell, and PC. In this study presented here, renal xenografts from animals received 1KO.1TG and 3KO.7TG donor pigs were used to acquire expression profiles of a total of 758 genes using nanostring - nCounter Human Organ Transplant Panel