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Transcription profiling by RNA-seq of zebrafish kidney marrow cells treated with Kitlga

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NIAID Data Ecosystem2026-05-01 收录
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Kit ligand (Kitlg) is a pleiotropic cytokine with a prominent role in vertebrate erythropoiesis. Due to whole genome duplication, zebrafish possess two copies of Kit ligand (Kitlga and Kitlgb). We generated a recombinant version of Kitlga, tested its biological activity in culture of zebrafish kidney marrow cells and performed RNA-seq analysis. Using this assay, we demonstrate that Kitlga cooperates with other factors to promote erythroid cell expansion ex vivo.

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2023-10-13
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