Crystal structure of dihydroorotate dehydrogenase from Leishmania braziliensis in complex with 5-(4-hydroxy-3-methoxybenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Crystal structure of dihydroorotate dehydrogenase from Leishmania braziliensis in complex with 5-(4-hydroxy-3-methoxybenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione Descriptor: 5-[(4-hydroxy-3-methoxyphenyl)methyl]-1,3-diazinane-2,4,6-trione, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... Authors: Froes, T.Q, Vaidergorn, M.M, Leite, P.I.P.L, Godoi, B.F, dos Santos, T, Emery, F.S, Nonato, M.C. Deposit date: 2025-02-05 Release date: 2025-07-23 Last modified: 2025-10-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Barbituric Acid Derivatives as Covalent Inhibitors of Leishmania braziliensis Dihydroorotate Dehydrogenase. J.Med.Chem., 68, 2025