High-throughput RNA sequencing reveals major alterations of inflammatory molecules involved in pathogenesis of peri- lesional psoriasis after NBUVB treatment

We report the high-throughput profiling of tissue biopsy in peri- lesion from psoriasis skin before the start of NB-UVB therapy and after treatment.RNA sequencing (RNA-Seq) was conducted to assay the transcriptomes and identify differentially expressed transcripts enriched in major pathway analysis. This study aimed to understand the mechanisms of psoriasis through analyzing differentially expressed genes with RNA-Seq technique by using phototherapy. This research was conducted in patients with moderate to severe plaque-type psoriasis who received NB-UVB treatment.