Prevalence of Apolipoprotein E genotypes and their association with Alzheimer’s disease among older adults in Uganda.

Alzheimer's disease (AD), a primary cause of dementia, is associated with genetic variations such as the APOE gene, which influences both the risk of AD and brain lipid metabolism. Notably, the APOE ε4 allele heightens the risk of AD, while the ε2 allele is protective. Despite extensive research on APOE variations and AD, data from sub-Saharan Africa remains sparse. This study aimed to address the gap in knowledge by investigating the prevalence of APOE alleles (ε2, ε3, and ε4) and genotypes among elderly individuals with Alzheimer's disease (AD) in Uganda. It was conducted using a case-control design, which included 86 older adults.