Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance.

ChEBI2014-12-07 更新2026-07-21 收录

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靶向治疗耐药性

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Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance.

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2014-12-07

ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [ChIP-seq]

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Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with Squamous Cell Carcinoma has identified SMAD4 to be frequently mutated. Here we used a novel m

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Autoinhibited BRAF:(14-3-3)2:MEK complex with the BRAF RBD resolved

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靶向药物设计

Autoinhibited BRAF:(14-3-3)2:MEK complex with the BRAF RBD resolved Descriptor: 14-3-3 protein zeta/delta, Dual specificity mitogen-activated protein kinase kinase 1, N-(3-fluoro-4-{[4-methyl-2-oxo-7-

Protein Data Bank Japan2025-05-28 更新60

Additional file 4: of Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals

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Table S4. miR-452-5p expression in RCC and normal renal samples from TCGA RCCÂ dataset. (XLS 137Â kb)

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Additional file 4: Table S3. of Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

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药物敏感性机制

Results of gene set enrichment analysis (GSEA) of the obtained three gene expression profiles of differences between sensitive and insensitive lung cancer cell lines. For that we used geneXplain platf

Figshare2018-02-14 更新60

Deep Phosphotyrosine Proteomics by Optimization of Phosphotyrosine Enrichment and MS/MS Parameters

磷酸化蛋白质组学

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Phosphorylation is a major post-translational modification that regulates protein function, with phosphotyrosine (pY) modifications being implicated in oncogenesis. However, global profiling of pY sta

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Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance.

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