Modulation of EBAG9 expression in CAR T cells
收藏NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJEB37843
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资源简介：
T cells engineered to express chimeric antigen receptors (CARs) have revolutionized treatment of B-cell malignancies. However, improving the efficacy of engineered T cells without compromising their safety is warranted. Here, we compared the transcriptional profile of human BCMA and EBAG9-modulated BCMA CAR T cells as the estrogen receptor-binding fragment-associated antigen 9 (EBAG9) inhibits the cytolytic capacity of CTLs. CAR T cells were generated from PBMCs of healthy volountary donors by retroviral transduction and were cultured for 10 days before CAR-expressing cells were sorted and RNA was extracted. Transcriptome analysis did not reveal additional risks regarding genotoxicity or differentiation due to EBAG9-modulation.
创建时间：
2022-07-27
