Solvent-Controlled, Tunable Domino Reaction of 3‑Ylideneoxindoles with in Situ-Generated α‑Aryldiazomethanes: A Facile Access to 3‑Spirocyclopropyl-2-oxindole and Pyrazoloquinazolinone Scaffolds
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A mild and efficient solvent-controlled, metal-free switchable 1,3-dipolar cycloaddition/ring contraction or ring expansion domino reaction of 3-ylideneoxindoles with in situ-generated α-aryldiazomethanes has been developed. This domino reaction provided a series of aryl-substituted 3-spirocyclopropyl-2-oxindoles and pyrazoloquinazolinones with excellent regio- and diastereoselectivity from common substrates under varying solvent conditions.
创建时间：
2018-10-01
