Deep learning approach identified a gene signature predictive of the severity of renal damage caused by chronic cadmium accumulation

Repetitive CdCl2 exposure resulted in cadmium accumulation and remarkable renal injuries in the animals. In the present study, we established an animal model to mimic chronic cadmium exposure-induced renal injury and performed whole transcriptome profiling studies. RNA-Seq data analysis showed that cadmium treatment induced dramatic gene expression changes in kidneys in a dose-dependent manner and higher severity of injury in ob/ob mice. Kidney mRNA profiles of CdCl2 treated ob/ob (ob) and normal C57BL/6 (b6j) mice