Human prolyl endopeptidase (PREP) - complex with YX45

Human prolyl endopeptidase (PREP) - complex with YX45 Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[4-chloro-1-(2-phenylethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1-(pyrrolidin-1-yl)ethan-1-one, DI(HYDROXYETHYL)ETHER, ... Authors: Fucci, I.J, Xie, Y, Yoo, E, Monteiro, D.C.F. Deposit date: 2025-08-21 Release date: 2026-01-21 Last modified: 2026-02-04 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition. J.Med.Chem., 69, 2026