Per-step pharmacodynamic dataset from VitalDB: propofol and remifentanil target-controlled infusion versus bispectral index

De-identified, analysis-ready per-step dataset for the analysis reported in "Asymmetric target-concentration–response relations of propofol and remifentanil on the bispectral index: a negative-control study of 50,918 steps" Contents- 01_data.zip: 84,926 rows — 50,918 real target-concentration steps (24,498 propofol, 26,420 remifentanil) and 34,008 randomly timed pseudo-steps used as negative controls, from 3,245 anaesthetics; plus a data dictionary giving the definition and unit of every column.- 02_code.zip: every Python script used to build the cohort, run the analyses and audit each reported number.- 03_outputs.zip: the result tables (CSV/Markdown) from which every number in the manuscript and supplement was taken.- MANIFEST.csv / SHA256SUMS.txt: integrity checksums. Provenance and ethicsSource: VitalDB (https://vitaldb.net), an open, de-identified database of 6,388 surgical casesrecorded at Seoul National University Hospital, August 2016 – June 2017. Original approval:IRB No. H-1408-101-605; ClinicalTrials.gov NCT02914444. Cite: Lee HC, Park Y, Yoon SB, Yang SM,Park D, Jung CW. VitalDB, a high-fidelity multi-parameter vital signs database in surgicalpatients. Sci Data 2022;9:279. doi:10.1038/s41597-022-01411-5.This study is a retrospective analysis of that public, de-identified resource. No interventionwas administered and no patient was under the authors' direct care, and this secondary analysisholds no ethical approval number of its own. De-identificationCase identifiers are study-specific (CASE_0001…CASE_3245); VitalDB caseid values are notincluded. Step identifiers are study-specific (STEP_000001…). All times are relative to thestart of recording for that case; no calendar date, birth date, name, record number orfree-text field is included. Licence: data CC BY 4.0; code MIT.