MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis

The goals of this study are to identify differentially expressed microRNAs in muscle between JDM and normal healthy controls, and to better understand the pathophysiology of JDM. Global microRNA expression from the skeletal muscle of 18 children with JDM and 6 healthy pediatric controls was performed on the miRCURY LNA™ microRNA Array (6'th GEN) using Exiqon microRNA array service (Skelstedet 16, 2950, Vedbak, Denmark) and was compared to determine differentially expressed microRNAs between JDM and healthy controls.