The Role of NRBP1 in Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is an aggressive subset of breast cancer associated with poor prognosis, defined by the absence of three key receptors . While combined chemoimmunotherapy is the standard of care, there is a lack of effective targeted therapies. NRBP1 is an oncogene in breast cancer, but the mechanisms of how it drives cancer are unclear. My thesis integrates bioinformatics, recombinant protein assays and mass spectrometric techniques to understand how NRBP1 functions in TNBC. I identified key cellular signalling mechanisms regulated by NRBP1, highlighting NRBP1 as a potential target for therapeutic intervention.