Whole genomic DNA methylation analysis across human polycystic ovary syndrome ovary granulosa cells [MBD-seq]

Aberration in miRNA expression or DNA methylation is a causal factor for numerous pathological conditions including polycystic ovarian syndrome PCOS, a common endocrine disorders and leading cause of infertility. The epigenetic interactions between miRNA and DNA methylation remain unexplored in PCOS. Our study identifies epigenetic alternation in ovarian granulosa cells from PCOS patients and helps to reveal the pathogenesis of PCOS. Overall design: In this study, we applied MBD sequencing in ovarian granulosa cells of PCOS patients and normal people.