One-Pot Dichotomous Construction of Inside-Azayohimban and Pro-Azayohimban Systems via an Enantioselective Organocatalytic Cascade; Their Use as a Model to Probe the (Aza-)Indole Local Solvent Environment
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https://figshare.com/articles/dataset/One_Pot_Dichotomous_Construction_of_Inside_Azayohimban_and_Pro_Azayohimban_Systems_via_an_Enantioselective_Organocatalytic_Cascade_Their_Use_as_a_Model_to_Probe_the_Aza_Indole_Local_Solvent_Environment/2103055
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资源简介：
A one-pot
enantioselective synthesis of 7-azaindole-octahydroisoquinolin-3-one
and an inside-aza-yohimbane system containing five contiguous stereogenic
centers with high enantioselectivities (>99% ee) was achieved. The prepared highly functionalized polycyclic system
provides a model for probing the solvent catalyzed proton transfer
reaction and mimicking the local environment of the tryptophan moiety
in proteins.
创建时间：
2016-02-12
