In silico analysis of all missense variants identified in AIPL1 in this study.

N/D = Unable to make a prediction due to lack of data.If all three programs agree that the change is pathological, then the consensus is disease causing. If one or two out of three programs agree with the variant being pathological, this is labelled uncertain. If all three agreed the change was benign (or in the case of polyphen 2 possibly damaging), then the variant is labelled a SNP (if rs number is available) or Benign rare variant.