RNA-Seq analysis SIRT1 overexpression effect on pancreatic tumor tissue in NOD/SCID mice

Name: RNA-Seq analysis SIRT1 overexpression effect on pancreatic tumor tissue in NOD/SCID mice
Creator: National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences
Published: 2022-02-20T00:00:00+08:00

干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录

胰腺癌研究

SIRT蛋白功能

数据链接：

http://data.iscr.ac.cn/Article?id=6263690897c8decb323be9d8ceba9836 数据链接链接失效反馈

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资源简介：

Pancreatic cancer is a common malignant tumor with poor prognosis. Accumulating evidence indicates that sirtuin 1 (SIRT1) exerts biological functions in various cancers.SIRT1 plays an important role in tumorigenesis, development, and drug resistance by blocking aging and apoptosis, also promoting cell growth and angiogenesis.However, how SIRT1 functions in the development of pancreatic cancer stem cells (CSCs) is currently poorly understood. Here, we showed that SIRT1 inhibits the differentiation of cancer cells by inhibiting various genes expression , including GRHL3, thus promoting the stemness and tumorigenesis of pancreatic cancer.

提供机构：

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences

创建时间：

2022-02-20