CD8+ cytotoxic T cells play essential roles in anti-tumor immune responses. Here, we performed in vivo screens in CD8+ T cells and identified regulators of tumor infiltration and killing, which are di

NIAID Data Ecosystem20

Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice [genomicDNA]

体内基因编辑

肥厚型心肌病

We assessed genome editing strategies to treat cardiomyopathy in mice including one or two doses of ABE8e, or one low, medium, or high dose of SaCas9 nuclease We conducted RNA analysis and genomic DNA

NIAID Data Ecosystem40

Outcomes of intrahepatic cholangiocarcinoma specific CRISPR screening in vivo [mouse exome]. Outcomes of intrahepatic cholangiocarcinoma specific CRISPR screening in vivo [mouse exome]

功能基因组学

体内基因编辑

We report the genertion of a gRNA library that induces mutations often found in intrahepatic cholangiocarcinoma. We use this to screen in vivo mutations that when lost act synergistically with mutant

NIAID Data Ecosystem20

in vivo base editing in adult dystrophic mice

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