EHMT1 and EHMT2 inhibition induce fetal hemoglobin expression
收藏官方服务:
资源简介:
EHMT1 and EHMT2 inhibition induce fetal hemoglobin expression
应用场景:
创建时间:
2015-11-02
相关数据集
A Genetic-to-Epigenetic Crosstalk Plays a Pivotal Role in the Promotion of KrasG12D-Induced Senescence and PanIN formation
Nupr1 is a chromatin protein which cooperates with KrasG12D to induce PanIN formation in mice, though the molecular mechanisms underlying this effect remain to be fully characterized. In the current s
NIAID Data Ecosystem70
Evaluation of global methylation profile in recipient BMMSCs of MRL/lpr mice after cell therapy (MeDip). Mus musculus
Mesenchymal stem cell transplantation (MSCT) has been widely used to treat a variety of human diseases. However, the detailed mechanisms underlying its success are not fully understood. Here we show t
NIAID Data Ecosystem30
Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons [ChIP-BS-Seq]
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function heterozygous mutations of MECP2. Reactivation of the silent wild-type MECP2 allele on the inactive X chromosom
NIAID Data Ecosystem30
Durable and efficient gene silencing in vivo by hit-and-run epigenome editing [WGMS]
Permanent epigenetic silencing with programmable editors equipped with transcriptional repressors holds great promise for the treatment of human diseases. However, to unlock its full therapeutic poten
NIAID Data Ecosystem50
Editing DNA Methylation in vivo [WGBS]
DNA methylation is an epigenetic mechanism essential for orchestrating gene expression. Precise editing of DNA methylation has emerged as a new method to dissect its biological function in a DNA seque
NIAID Data Ecosystem30



