Extrachromosomal circular DNA (eccDNA) characteristics in the bile and plasma of advanced perihilar cholangiocarcinoma patients

Extrachromosomal DNAs (eccDNAs) frequently carry amplifiedoncogenes. This investigation aimed to examine the occurrence and role ofeccDNAs in individuals diagnosed with advanced perihilar cholangiocarcinoma(pCCA) who exhibited distinct prognostic outcomes.